Biography | Publications
Dr. Cline recently joined Kitware, part-time. Dr. Cline’s research at Kitware involves improving both computed tomography coronary artery segmentation and visualization wherein non-invasive cardiac CT exams can be used to obviate the need for invasive angiography in symptomatic patients with normal coronary arteries.  Over the past 40 years at GE Global Research, he has worked in a variety of technical areas; namely, superconductivity, composite solidification, semiconductor processing, laser processing, computer algorithms, computer visualization, medical image processing, image guided surgery, surgical planning and molecular imaging.

In 1984, he co-invented the Marching Cubes algorithm for creating three-dimensional polygonal surfaces from medical images. The initial application was creating three-dimensional surfaces from computer tomography (CT) images, Dr. Cline then changed organizations from physical science to the magnetic resonance (MR) program and worked on 3D MR angiography, segmentation algorithms for three-dimensional MR brain and cardiac imaging. In (1987-1995), Dr. Cline worked with GE colleagues in a Research Workstation project with computer scientists from over 100 teaching hospitals that met twice a year to discuss medical imaging applications. Dr. Cline collaborated with Brigham and Women’s Hospital in both surgical planning and MR guided focused ultrasound thermal ablation. Dr. Cline developed MR thermal imaging for computer control of a focused ultrasound beam and helped develop clinical prototypes for clinical trials. He worked on parallel MRI cardiac imaging to detect coronary arteries. Dr. Clines applied computer algorithms in different medical modalities; namely, magnetic resonance imaging MRI, multi-detector computed tomography MDCT, 3D ultrasound US, positron emission tomography PET, and digital microscopy for pathology.

Dr. Cline received his Ph.D. in Material Science and B.S. in Physics from the Massachusetts Institute of Technology in Cambridge Massachusetts for research in superconductivity, 1965 and 1962. He was awarded a Coolidge Fellowship in 1979 and studied Physics at Stanford University. He published more than 100 papers and holds more than 175 patents, was awarded inventor of the year for magnetic resonance angiography, and is a member of the National Academy of Engineering. Dr. Cline retired from GE Global Research in February 2007.


Selected Publications

WE Lorensen, HE Cline Marching Cubes: A High Resolution Surface Construction Algorithm Computer Graphics (1987)

HE Cline, WE Lorensen, S Ludke, CR Crawford, BC Teeter Two algorithms for three-dimensional reconstruction of tomograms Medical Physics 15 (3) 320 (1988)

CJ Hardy, HE Cline Broadband Nuclear Magnetic Resonance Pulses with Two-Dimensional Spatial Selectivity Journal of Applied Physics 66 ,1513 (1989)

JD Pearlman, CJ Hardy, HE Cline Continuous NMR Cardiography without Gating: M-Mode MRI Radiology 175, 369-373 (1990)

HE Cline. WE Lorensen, R Kikinis, F Jolesz 3D Segmentation of the Head Using Probability and Connectivity Journal of Computer Assisted Tomography 14:1037-1045 (1990)

FA Jolesz, R Kikinis, H.E. Cline WE Lorensen, G Gerig 3-D View of the Brain Using MRI: Computerized Image Processing Hospimedica 8,20 (1990)

HE Cline, WE Lorensen, SP Souza, FA Jolesz, R Kikinis, G Gerig, TE Kennedy 3D Surface Rendered MR Images of the Brain and Its Vasculature Journal of Computer Assisted Tomography 15, 344-351 (1991)

HE Cline, WE Lorensen, WJ Schroeder Three Dimensional Phase Contrast Magnetic Resonance Blood Flow And Surface Anatomy Journal of Computer Assisted Tomography 17, 173-177 (1993)

HE Cline, K Hynynen, CT Hardy, RD Watkins, JF Schenck, FA Jolesz Temperature Mapping of Focused Ultrasound Surgery Magnetic Resonance in Medicine 31 628-636 (1994)

HE Cline, CL Dumoulin, WE Lorensen, SP Souza, WJ Adams Volume Rendering Connectivity Algorithms for MR Angiography Magnetic Resonance in Medicine 18,384-394 (1991)

DE Altobelli, R Kikinis, JB Mulliken, HE Cline, WE Lorensen, FA Jolesz Computer-Assisted Three-Dimensional Planning in Craniofacial Surgery Plastic and Reconstructive Surgery 92, 576-587 (1993)

HE Cline, WE Lorensen, WJ Schroeder Three Dimensional Phase Contrast Magnetic Resonance Blood Flow And Surface Anatomy Journal of Computer Assisted Tomography 17, 173-177 (1993)

HE Cline, K Hynynen,, RD Watkins, et al. A Focused Ultrasound System for MRI Guided Ablation. Radiology 194, 731-737 (1995)

HE Cline, K Hynynen, E Schnieder, CJ Hardy, SE Maier, RD Watkins, FA Jolesz Simultaneous Magnetic Resonance Phase and Magnitude Temperature Maps in Muscle Magnetic Resonance in Medicine 35, 308-315 (1996)

HE Cline, DR Thedens, P Irarrazaval, CH Meyer, BS Hu, DG Nishimura, S. Ludke 3D MR Coronary Artery Segmentation Magnetic Resonance in Medicine 39, 697-702 (1998)

HE. Cline, C. Coulam, M. Yavuz, G.D. Rubin, P. Edic, T. Pan, Y. Shen, R. Avila, M. Turek, M. Iatrou, A. Loree, N. Ishaque. R. Senzig Coronary Artery Angiography Using Multislice Computed Tomography Images Circulation 2000;102:1589-15

HE Cline, Xuli Zong, Neville Gai Design of a Logarithmic k-space Spiral Trajectory Magnetic Resonance in Medicine 46:1130-1135 (2001)

E.E. Uzgiris, Harvey Cline, Bahram Moasser, Brian Grimmond, Mohan Amaratunga, Joanne F. Smith, Gregory Goddard Conformation and Structure of Polymeric Contrast Agents for Medical Imaging Biomacromolecules 2004;5 : 54-61.

HE Cline, R, Mallozzi Li Zhu, G McKinnon, W Barber Radiofrequency Power Deposition Utilizing Thermal Imaging Magnetic Resonance in Medicine 51:1129-1137 (2004)

CH Hardy, HE Cline, RO Giaquinto, T Niendorf, AK Grant, DK Sodikson 32-Element Receiver-Coil Array for Cardiac Imaging Magnetic Resonance in Medicine 55:1142-1149 (2006)