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Dr. Cline recently joined Kitware part time. Over the past 40 years at GE
Global Research, he has worked in a variety of technical areas; namely,
superconductivity, composite solidification, semiconductor processing, laser
processing, computer algorithms, computer visualization, medical image
processing, image guided surgery, surgical planning and molecular imaging.
In 1984, He co-invented the Marching Cubes algorithm for creating
three-dimensional polygonal surfaces from medical images. The initial
application was creating three-dimensional surfaces from computer tomography
(CT) images, Dr Cline then changed organizations from physical science to the
magnetic resonance (MR) program and worked on 3D MR angiography, segmentation
algorithms for three-dimensional MR brain and cardiac imaging. In (1987-1995),
Dr Cline worked with GE colleagues in a Research Workstation project with
computer scientists from over 100 teaching hospitals that met twice a year to
discuss medical imaging applications. Dr Cline collaborated with Brigham and
Women’s Hospital in both surgical planning and MR guided focused ultrasound
thermal ablation. Dr. Cline developed MR thermal imaging for computer control
of a focused ultrasound beam and helped develop clinical prototypes for
clinical trials. He worked on parallel MRI cardiac imaging to detect coronary
arteries. Dr Clines applied computer algorithms in different medical
modalities; namely, magnetic resonance imaging MRI, multi-detector computed
tomography MDCT, 3D ultrasound US, positron emission tomography PET, and
digital microscopy for pathology.
Dr. Cline received his PhD in Material Science and BS in Physics from the
Massachusetts Institute of Technology in Cambridge Massachusetts for research
in superconductivity, 1965 and 1962. He was awarded a Coolidge Fellowship in
1979 and studied Physics at Stanford University. He published more than 100
papers and holds more than 175 patents, awarded Inventor of the year for
Magnetic Resonance angiography, and is a member of the National Academy of
Engineering. Dr Cline retired from GE Global Research in Feb. 2007.
Selected Publications
WE Lorensen, HE Cline
Marching Cubes: A High Resolution Surface Construction Algorithm
Computer Graphics (1987)
HE Cline, WE Lorensen, S Ludke, CR Crawford, BC Teeter
Two algorithms for three-dimensional reconstruction of tomograms
Medical Physics 15 (3) 320 (1988)
CJ Hardy, HE Cline
Broadband Nuclear Magnetic Resonance Pulses with Two-Dimensional Spatial Selectivity
Journal of Applied Physics 66 ,1513 (1989)
JD Pearlman, CJ Hardy, HE Cline
Continuous NMR Cardiography without Gating: M-Mode MRI
Radiology 175, 369-373 (1990)
HE Cline. WE Lorensen, R Kikinis, F Jolesz
3D Segmentation of the Head Using Probability and Connectivity
Journal of Computer Assisted Tomography 14:1037-1045 (1990)
FA Jolesz, R Kikinis, H.E. Cline WE Lorensen, G Gerig
3-D View of the Brain Using MRI: Computerized Image Processing
Hospimedica 8,20 (1990)
HE Cline, WE Lorensen, SP Souza, FA Jolesz, R Kikinis, G Gerig, TE Kennedy
3D Surface Rendered MR Images of the Brain and Its Vasculature
Journal of Computer Assisted Tomography 15, 344-351 (1991)
HE Cline, WE Lorensen, WJ Schroeder
Three Dimensional Phase Contrast Magnetic Resonance Blood Flow And Surface Anatomy
Journal of Computer Assisted Tomography 17, 173-177 (1993)
HE Cline, K Hynynen, CT Hardy, RD Watkins, JF Schenck, FA Jolesz
Temperature Mapping of Focused Ultrasound Surgery
Magnetic Resonance in Medicine 31 628-636 (1994)
HE Cline, CL Dumoulin, WE Lorensen, SP Souza, WJ Adams
Volume Rendering Connectivity Algorithms for MR Angiography
Magnetic Resonance in Medicine 18,384-394 (1991)
DE Altobelli, R Kikinis, JB Mulliken, HE Cline, WE Lorensen, FA Jolesz
Computer-Assisted Three-Dimensional Planning in Craniofacial Surgery
Plastic and Reconstructive Surgery 92, 576-587 (1993)
HE Cline, WE Lorensen, WJ Schroeder
Three Dimensional Phase Contrast Magnetic Resonance Blood Flow And Surface Anatomy
Journal of Computer Assisted Tomography 17, 173-177 (1993)
HE Cline, K Hynynen,, RD Watkins, et al.
A Focused Ultrasound System for MRI Guided Ablation.
Radiology 194, 731-737 (1995)
HE Cline, K Hynynen, E Schnieder, CJ Hardy, SE Maier, RD Watkins, FA Jolesz
Simultaneous Magnetic Resonance Phase and Magnitude Temperature Maps in Muscle
Magnetic Resonance in Medicine 35, 308-315 (1996)
HE Cline, DR Thedens, P Irarrazaval, CH Meyer, BS Hu, DG Nishimura, S. Ludke
3D MR Coronary Artery Segmentation
Magnetic Resonance in Medicine 39, 697-702 (1998)
HE. Cline, C. Coulam, M. Yavuz, G.D. Rubin, P. Edic, T. Pan, Y. Shen, R. Avila, M. Turek, M. Iatrou, A. Loree, N. Ishaque. R. Senzig
Coronary Artery Angiography Using Multislice Computed Tomography Images
Circulation 2000;102:1589-15
HE Cline, Xuli Zong, Neville Gai
Design of a Logarithmic k-space Spiral Trajectory
Magnetic Resonance in Medicine 46:1130-1135 (2001)
E.E. Uzgiris, Harvey Cline, Bahram Moasser, Brian Grimmond, Mohan Amaratunga, Joanne F. Smith, Gregory Goddard
Conformation and Structure of Polymeric Contrast Agents for Medical Imaging
Biomacromolecules 2004;5 : 54-61.
HE Cline, R, Mallozzi Li Zhu, G McKinnon, W Barber
Radiofrequency Power Deposition Utilizing Thermal Imaging
Magnetic Resonance in Medicine 51:1129-1137 (2004)
CH Hardy, HE Cline, RO Giaquinto, T Niendorf, AK Grant, DK Sodikson
32-Element Receiver-Coil Array for Cardiac Imaging
Magnetic Resonance in Medicine 55:1142-1149 (2006)
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