Stephen Aylward

Stephen Aylward

Senior Director of Strategic Initiatives

Dr. Aylward is Senior Director of Strategic Initiatives and the founder of Kitware’s office in North Carolina. He also helps direct Kitware’s medical research activities. At the University of North Carolina at Chapel Hill (UNC), Dr. Aylward is an adjunct associate professor in the Department of Computer Science. He is an elected member of the executive board of the Medical Image Computing and Computer Assisted Intervention (MICCAI) society. He also is an associate editor for IEEE Transactions on Medical Imaging and the SPIE Journal of Medical Imaging, and he serves on several conference and academic advisory committees. Prior to joining Kitware, Dr. Aylward was a tenured associate professor of Radiology, Computer Science, and Surgery at UNC.

In general, Dr. Aylward’s research has focused on vascular image analysis, computer-aided diagnosis, point-of-care ultrasound applications, and the Insight Segmentation and Registration Toolkit (ITK) and other open-source toolkits. He has had Small Business Innovation Research (SBIR), Small Business Technology Transfer (STTR), and Research Project (R01) grants from the National Institutes of Health (NIH), National Science Foundation (NSF), and Department of Defense (DoD) to (a) work with a small businesses to develop a low-cost, easy-to-use ultrasound system that helps novice users assess intra-abdominal bleeding for trauma victims in the field, (b) assist a university professor to study the micro-vasculature of tumors using micro-bubble contrast agents to grade cancers and to study their response to treatment, (c) assist a small business to create a commercial ultrasound system that forms whole body 3D ultrasound scans of mice to detect genetic variations and to characterize disease, (d) enhance the capabilities of the Visualization Toolkit (VTK) for medical imaging, and (e) collaborate with leading institutions on the study of traumatic brain injury. Dr. Aylward has been involved in these and related research areas for nearly 25 years.

  1. X. Han, X. Yang, S. Aylward, R. Kwitt, and M. Niethammer, "Efficient registration of pathological images: a joint pca/image-reconstruction approach," arXiv preprint arXiv:1704.00036, 2017.
  2. S. R. Aylward et al., "Ultrasound spectroscopy," in Biomedical Imaging (ISBI), 2016 IEEE 13th International Symposium on, 2016, pp. 1013--1016.
  3. T. Kapur, S. Pieper, A. Fedorov, J. Fillion-Robin, M. Halle, L. O'donnell, A. Lasso, T. Ungi, C. Pinter, J. Finet, and others, "Increasing the impact of medical image computing using community-based open-access hackathons: The NA-MIC and 3D Slicer experience," 2016.
  4. S. E. Shelton, P. A. Dayton, S. R. Aylward, and F. S. Foster, "The application of acoustic angiography to assess the progression of angiogenesis in a spontaneous mouse model of breast cancer," in Ultrasonics Symposium (IUS), 2016 IEEE International, 2016, pp. 1--3.
  5. S. E. Shelton, B. D. Lindsey, R. Gessner, Y. Lee, S. Aylward, H. Lee, E. Cherin, F. S. Foster, and P. A. Dayton, "Acoustic angiography: a new high frequency contrast ultrasound technique for biomedical imaging," in SPIE Commercial+ Scientific Sensing and Imaging, 2016, pp. 987109--987109.
  6. X. Yang, X. Han, E. Park, S. Aylward, R. Kwitt, and M. Niethammer, "Registration of pathological images," in International Workshop on Simulation and Synthesis in Medical Imaging, 2016, pp. 97--107.
  7. X. Liu, M. Niethammer, R. Kwitt, N. Singh, M. McCormick, and S. Aylward, "Low-rank atlas image analyses in the presence of pathologies," IEEE transactions on medical imaging, vol. 34, no. 12, pp. 2583--2591, 2015.
  8. B. Paniagua, D. Zukic, R. Ortiz, S. Aylward, B. Golden, T. Nguyen, and A. Enquobahrie, "Ultrasound-guided navigation system for orthognathic surgery," in Workshop on Augmented Environments for Computer-Assisted Interventions, 2015, pp. 1--10.
  9. S. E. Shelton, Y. Z. Lee, M. Lee, E. Cherin, F. S. Foster, S. R. Aylward, and P. A. Dayton, "Quantification of microvascular tortuosity during tumor evolution using acoustic angiography," Ultrasound in medicine \& biology, vol. 41, no. 7, pp. 1896--1904, 2015.
  10. S. Aylward and L. M. Hadjiiski, "Medical imaging 2014: computer-aided diagnosis," in Medical Imaging 2014: Computer-Aided Diagnosis, 2014.
  11. J. Finet, R. Ortiz, J. Andruejol, A. Enquobahrie, J. Jomier, J. Payne, and S. Aylward, "Bender: an open source software for efficient model posing and morphing," in International Symposium on Biomedical Simulation, 2014, pp. 203--210.
  12. R. Kwitt, S. Razzaque, J. Lowell, and S. Aylward, "Variability sensitivity of dynamic texture based recognition in clinical ct data," in SPIE Medical Imaging, 2014, pp. 903420--903420.
  13. X. Liu, M. Niethammer, R. Kwitt, M. McCormick, and S. Aylward, "Low-rank to the rescue--atlas-based analyses in the presence of pathologies," in International Conference on Medical Image Computing and Computer-Assisted Intervention, 2014, pp. 97--104.
  14. C. Mullins, R. Gessner, and S. Aylward, "Using tubetk to automatically merge volumes," Insight Journal, 2014.
  15. S. Aylward, "Trends and challenges in open source software (presentation video)," in SPIE Optical Engineering+ Applications, 2013, pp. 885501--885501.
  16. A. Enquobahrie, V. Shivaprabhu, S. Aylward, J. Finet, K. Cleary, and R. Alterovitz, "Patient-specific port placement for laparoscopic surgery using atlas-based registration," in SPIE Medical Imaging, 2013, pp. 86711M--86711M.
  17. A. Enquobahrie, V. Shivaprabhu, S. Aylward, J. Finet, K. Cleary, and R. Alterovitz, "Medical imaging 2013: image-guided procedures, robotic interventions, and modeling," in Medical Imaging 2013: Image-Guided Procedures, Robotic Interventions, and Modeling, 2013.
  18. R. C. Gessner, A. D. Hanson, S. Feingold, A. T. Cashion, A. Corcimaru, B. T. Wu, C. R. Mullins, S. R. Aylward, L. M. Reid, and P. A. Dayton, "Functional ultrasound imaging for assessment of extracellular matrix scaffolds used for liver organoid formation," Biomaterials, vol. 34, no. 37, pp. 9341--9351, 2013.
  19. R. Kwitt, D. Pace, M. Niethammer, and S. Aylward, "Studying cerebral vasculature using structure proximity and graph kernels," in International Conference on Medical Image Computing and Computer-Assisted Intervention, 2013, pp. 534--541.
  20. R. Kwitt, N. Vasconcelos, S. Razzaque, and S. Aylward, "Localizing target structures in ultrasound video--a phantom study," Medical image analysis, vol. 17, no. 7, pp. 712--722, 2013.
  21. C. L. Novak and S. Aylward, "Medical imaging 2013: computer-aided diagnosis," in Medical Imaging 2013: Computer-Aided Diagnosis, 2013.
  22. C. L. Novak and S. Aylward, "Computer-aided diagnosis," in Proc. of SPIE Vol, 2013, pp. 867001--1.
  23. D. F. Pace, S. R. Aylward, and M. Niethammer, "A locally adaptive regularization based on anisotropic diffusion for deformable image registration of sliding organs," IEEE transactions on medical imaging, vol. 32, no. 11, pp. 2114--2126, 2013.
  24. B. Paniagua, O. Emodi, J. Hill, J. Fishbaugh, L. A. Pimenta, S. R. Aylward, E. Andinet, G. Gerig, J. Gilmore, A. J. A. Van, and others, "3d of brain shape and volume after cranial vault remodeling surgery for craniosynostosis correction in infants," in SPIE Medical Imaging, 2013, pp. 86720V--86720V.
  25. V. R. Shivaprabhu, A. Enquobahrie, Z. Mullen, and S. Aylward, "Accelerating ultrasound image analysis research through publically available database," in SPIE Medical Imaging, 2013, pp. 867517--867517.
  26. S. Aylward et al., "Methods, systems, and computer program products for hierarchical registration between a blood vessel and tissue surface model for a subject and a blood vessel and tissue surface image for the subject," Jul. 2012.
  27. A. Fedorov, R. Beichel, J. Kalpathy-Cramer, J. Finet, J. Fillion-Robin, S. Pujol, C. Bauer, D. Jennings, F. Fennessy, M. Sonka, and others, "3d slicer as an image computing platform for the quantitative imaging network," Magnetic resonance imaging, vol. 30, no. 9, pp. 1323--1341, 2012.
  28. R. C. Gessner, S. R. Aylward, and P. A. Dayton, "Imaging tortuosity: the potential utility of acoustic angiography in cancer detection and tumor assessment," Imaging, vol. 4, no. 6, pp. 581--583, 2012.
  29. R. C. Gessner, S. R. Aylward, and P. A. Dayton, "Mapping microvasculature with acoustic angiography yields quantifiable differences between healthy and tumor-bearing tissue volumes in a rodent model," Radiology, vol. 264, no. 3, pp. 733--740, 2012.
  30. A. Irimia, B. Wang, S. R. Aylward, M. W. Prastawa, D. F. Pace, G. Gerig, D. A. Hovda, R. Kikinis, P. M. Vespa, and H. J. D. Van, "Neuroimaging of structural pathology and connectomics in traumatic brain injury: toward personalized outcome prediction," NeuroImage: Clinical, vol. 1, no. 1, pp. 1--17, 2012.
  31. T. Kapur, S. Pieper, R. Whitaker, S. Aylward, M. Jakab, W. Schroeder, and R. Kikinis, "The national alliance for medical image computing, a roadmap initiative to build a free and open source software infrastructure for translational research in medical image analysis," Journal of the American Medical Informatics Association, vol. 19, no. 2, pp. 176--180, 2012.
  32. R. Kwitt, N. Vasconcelos, S. Razzaque, and S. Aylward, "Recognition in ultrasound videos: where am i?," Medical Image Computing and Computer-Assisted Intervention--MICCAI 2012, pp. 83--90, 2012.
  33. D. F. Pace, M. Niethammer, and S. R. Aylward, "Abdominal imaging: computational and clinical applications-third international workshop, held in conjunction with miccai 2011, revised selected papers," in 3rd International Workshop on Computational and Clinical Applications in Abdominal Imaging, Held in Conjunction with the 14th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2011, 2012.
  34. D. Testi, D. Giunchi, G. Clapworthy, S. Aylward, X. Planes, and R. Christie, "New interactive visualisation of multiscale biomedical data," in ACM SIGGRAPH 2012 Posters, 2012, p. 76.
  35. M. A. Audette, D. Rivière, C. Law, L. Ibanez, S. R. Aylward, J. Finet, X. Wu, and M. G. Ewend, "Approach-specific multi-grid anatomical modeling for neurosurgery simulation with public-domain and open-source software," in SPIE Medical Imaging, 2011, pp. 79642J--79642J.
  36. M. Niethammer, G. L. Hart, D. F. Pace, P. M. Vespa, A. Irimia, H. J. D. Van, and S. R. Aylward, "Geometric metamorphosis," in International Conference on Medical Image Computing and Computer-Assisted Intervention, 2011, pp. 639--646.
  37. D. F. Pace, A. Enquobahrie, H. Yang, S. R. Aylward, and M. Niethammer, "Deformable image registration of sliding organs using anisotropic diffusive regularization," in Biomedical Imaging: From Nano to Macro, 2011 IEEE International Symposium on, 2011, pp. 407--413.
  38. D. F. Pace, M. Niethammer, and S. R. Aylward, "Sliding geometries in deformable image registration," in International MICCAI Workshop on Computational and Clinical Challenges in Abdominal Imaging, 2011, pp. 141--148.
  39. D. Testi, G. Clapworthy, S. Aylward, A. Frangi, and R. Christie, "Interactive visualization of multiscale biomedical data: an integrated approach," in Proceedings of the 1st IEEE Symposium on Biological Data Visualization (BioVis), 2011, pp. 3--4.
  40. E. Bullitt, D. Zeng, B. Mortamet, A. Ghosh, S. R. Aylward, W. Lin, B. L. Marks, and K. Smith, "The effects of healthy aging on intracerebral blood vessels visualized by magnetic resonance angiography," Neurobiology of aging, vol. 31, no. 2, pp. 290--300, 2010.
  41. R. C. Gessner, R. Kothadia, S. Feingold, S. Aylward, E. Bullitt, and P. A. Dayton, "Blood vessel structural morphology derived from 3d dual-frequency ultrasound images," in Ultrasonics Symposium (IUS), 2010 IEEE, 2010, pp. 209--212.
  42. E. Bullitt, M. Ewend, J. Vredenburgh, A. Friedman, W. Lin, K. Wilber, D. Zeng, S. R. Aylward, and D. Reardon, "Computerized assessment of vessel morphological changes during treatment of glioblastoma multiforme: report of a case imaged serially by mra over four years," Neuroimage, vol. 47, pp. T143--T151, 2009.
  43. J. Jomier, S. R. Aylward, C. Marion, J. Lee, and M. Styner, "A digital archiving system and distributed server-side processing of large datasets," in SPIE Medical Imaging, 2009, pp. 726413--726413.
  44. J. Lee, J. Jomier, S. Aylward, M. Tyszka, S. Moy, J. Lauder, and M. Styner, "Evaluation of atlas based mouse brain segmentation," in SPIE Medical Imaging, 2009, pp. 725943--725943.
  45. G. Piliere, H. M. H. Van, R. Dixon, J. Stavas, S. Aylward, and E. Bullitt, "Vessel target location estimation during the tips procedure," Medical image analysis, vol. 13, no. 3, pp. 519--529, 2009.
  46. I. Oguz, J. Cates, T. Fletcher, R. Whitaker, D. Cool, S. Aylward, and M. Styner, "Cortical correspondence using entropy-based particle systems and local features," in Biomedical Imaging: From Nano to Macro, 2008. ISBI 2008. 5th IEEE International Symposium on, 2008, pp. 1637--1640.
  47. Z. Zhao, D. Wallace, S. Freedman, and S. Aylward, "A tool for computer-aided diagnosis of retinopathy of prematurity [6915-104]," in PROCEEDINGS-SPIE THE INTERNATIONAL SOCIETY FOR OPTICAL ENGINEERING, 2008, p. 6915.
  48. Z. Zhao, D. K. Wallace, S. F. Freedman, and S. R. Aylward, "A tool for computer-aided diagnosis of retinopathy of prematurity," in Medical Imaging, 2008, pp. 69152W--69152W.
  49. S. Aylward et al., "Optimizing itk’s registration methods for multi-processor, shared-memory systems," Insight Journal, 2007.
  50. E. Bullitt, S. R. Aylward, D. T. Van, and W. Lin, "Computer-assisted measurement of vessel shape from 3t magnetic resonance angiography of mouse brain," Methods, vol. 43, no. 1, pp. 29--34, 2007.
  51. P. Cheng, L. Ibanez, D. Gobbi, K. Gary, S. Aylward, J. Jomier, A. Enquobahrie, H. Zhang, H. Kim, and M. Blake, "The image-guided surgery toolkit igstk: an open source c++ software toolkit [6516-09]," in PROCEEDINGS-SPIE THE INTERNATIONAL SOCIETY FOR OPTICAL ENGINEERING, 2007, p. 65160A.
  52. P. Cheng, L. Ibanez, D. Gobbi, K. Gary, S. Aylward, J. Jomier, A. Enquobahrie, H. Zhang, H. Kim, M. B. Blake, and others, "The image-guided surgery toolkit igstk: an open source c++ software toolkit," in Medical Imaging, 2007, pp. 65160A--65160A.
  53. S. DiMaio, T. Kapur, K. Cleary, S. Aylward, P. Kazanzides, K. Vosburgh, R. Ellis, J. Duncan, K. Farahani, H. Lemke, and others, "Challenges in image-guided therapy system design," NeuroImage, vol. 37, pp. S144--S151, 2007.
  54. A. Enquobahrie, P. Cheng, K. Gary, L. Ibanez, D. Gobbi, F. Lindseth, Z. Yaniv, S. Aylward, J. Jomier, and K. Cleary, "The image-guided surgery toolkit igstk: an open source c++ software toolkit," Journal of Digital Imaging, vol. 20, no. 1, pp. 21--33, 2007.
  55. P. Reynolds, J. Jomier, and S. Aylward, "Midas Module for Accessing Slicer Tutorial Data," 2007.
  56. P. Cheng, H. Zhang, H. Kim, K. Gary, M. B. Blake, D. Gobbi, S. Aylward, J. Jomier, A. Enquobahrie, R. Avila, and others, "Igstk: framework and example application using an open source toolkit for image-guided surgery applications," in Medical Imaging, 2006, pp. 61411Y--61411Y.
  57. K. Gary, L. Ibanez, S. Aylward, D. Gobbi, M. B. Blake, and K. Cleary, "Igstk: an open source software toolkit for image-guided surgery," Computer, vol. 39, no. 4, pp. 46--53, 2006.
  58. L. Ibáñez, R. Avila, and S. Aylward, "Open source and open science: how it is changing the medical imaging community," in Biomedical Imaging: Nano to Macro, 2006. 3rd IEEE International Symposium on, 2006, pp. 690--693.
  59. J. Jomier, E. Bullitt, H. M. Van, C. Pathak, and S. R. Aylward, "3d/2d model-to-image registration applied to tips surgery," in International Conference on Medical Image Computing and Computer-Assisted Intervention, 2006, pp. 662--669.
  60. J. Peyre, J. Smith, J. Jomier, F. Castellano, S. Aylward, and M. Castill, "Systemic Lupus Erythematosus CNS Vasculitis: circulatory pathology demonstrated with perfusion MRI," 2006.
  61. S. Aylward et al., "Intraoperative image processing for surgical guidance," IEEE transactions on medical imaging, vol. 24, no. 11, pp. 1401--1404, 2005.
  62. S. Aylward et al., "Spatial graphs for intra-cranial vascular network characterization, generation, and discrimination," Medical Image Computing and Computer-Assisted Intervention--MICCAI 2005, pp. 59--66, 2005.
  63. M. B. Blake, K. Cleary, H. Kim, S. Ranjan, K. Gary, J. Jomier, S. Aylward, and L. Ibanez, "Component-based design and development for robust medical applications," in High Confidence Medical Device Software and Systems (HCMDSS) Workshop, 2005.
  64. E. Bullitt and S. Aylward, "Visualizing blood vessel trees in three dimensions: clinical applications," in Medical Imaging, 2005, pp. 67--78.
  65. E. Bullitt, K. E. Muller, I. Jung, W. Lin, and S. Aylward, "Analyzing attributes of vessel populations," Medical image analysis, vol. 9, no. 1, pp. 39--49, 2005.
  66. E. Bullitt, D. Zeng, G. Gerig, S. Aylward, S. Joshi, J. K. Smith, W. Lin, and M. G. Ewend, "Vessel tortuosity and brain tumor malignancy: a blinded study1," Academic radiology, vol. 12, no. 10, pp. 1232--1240, 2005.
  67. E. B. Cole, E. D. Pisano, D. Zeng, K. Muller, S. R. Aylward, S. Park, C. Kuzmiak, M. Koomen, D. Pavic, R. Walsh, and others, "The effects of gray scale image processing on digital mammography interpretation performance 1," Academic radiology, vol. 12, no. 5, pp. 585--595, 2005.
  68. D. Dalal, J. Jomier, and S. Aylward, "A dicom-based software infrastructure for data archiving," in The Insight Journal--2005 MICCAI Open-Source Workshop. Available from, 2005.
  69. K. Gary, B. Blake, S. Aylward, J. Jomier, D. Gobbi, H. S. Kim, R. Avila, L. Ibanez, and K. Cleary, "IGSTK: Development Process and Project Management Best Practices for an Open Source Software Toolkit for Image-Guided Surgery Applications," 2005.
  70. L. Ibanez, J. Jomier, D. Gobbi, R. Avila, M. B. Blake, H. Kim, K. Gary, S. Aylward, and K. Cleary, "Igstk: a state machine architecture for an open source software toolkit for image-guided surgery applications," in Insight Journal—MICCAI Open-Source Workshop, 2005.
  71. L. Ibanez, G. Kindlmann, and S. Aylward, "Hot topics in 3d medical image visualization," in ACM SIGGRAPH 2005 Courses, 2005, p. 1.
  72. J. Jomier, V. LeDigarcher, and S. Aylward, "Automatic vascular tree formation using the mahalanobis distance," Medical Image Computing and Computer-Assisted Intervention--MICCAI 2005, pp. 806--812, 2005.
  73. J. Jomier, V. LeDigarcher, and S. Aylward, "Comparison of vessel segmentations using staple," Medical Image Computing and Computer-Assisted Intervention--MICCAI 2005, pp. 523--530, 2005.
  74. K. Kocis, C. Kuroda, W. Sternberger, J. Michael, L. Ramac-Thomas, S. Daniels, S. Aylward, J. Kim, D. Nichols, J. Gotsis, and others, "Quantifying diaphragm function with ultrasound: development in a piglet model of diaphragm fatigue: 19," Pediatric Critical Care Medicine, vol. 6, no. 1, p. 107, 2005.
  75. D. Shelton, G. Stetten, S. Aylward, L. Ibáñez, A. Cois, and C. Stewart, "Teaching medical image analysis with the insight toolkit," Medical image analysis, vol. 9, no. 6, pp. 605--611, 2005.
  76. T. Yoo, D. Metaxas, V. Arsigny, X. Pennec, N. Ayache, T. Sundaram, J. Gee, B. d. A. A. du, C. M. De, X. Geets, and others, "Special issue on itk," Medical Image Analysis, vol. 9, no. 6, 2005.
  77. Z. Zhao, S. R. Aylward, and E. K. Teoh, "A novel 3d partitioned active shape model for segmentation of brain mr images," in International Conference on Medical Image Computing and Computer-Assisted Intervention, 2005, pp. 221--228.
  78. S. R. Aylward et al., "Systems and methods for tubular object processing," Feb. 2004.
  79. S. R. Aylward and J. Kim, "Statistics of pattern recognition," in Insight into Images: Principles and Practice for Segmentation, Registration, and Image Analysis, , Ed., AK Peters/CRC Press, 2004, pp. 47--101.
  80. E. Bullitt, M. G. Ewend, S. Aylward, W. Lin, G. Gerig, S. Joshi, I. Jung, K. Muller, and J. K. Smith, "Abnormal vessel tortuosity as a marker of treatment response of malignant gliomas: preliminary report," Technology in cancer research \& treatment, vol. 3, no. 6, pp. 577--584, 2004.
  81. E. Bullitt, I. Jung, K. Muller, G. Gerig, S. Aylward, S. Joshi, K. Smith, W. Lin, and M. Ewend, "Determining malignancy of brain tumors by analysis of vessel shape," Medical Image Computing and Computer-Assisted Intervention--MICCAI 2004, pp. 645--653, 2004.
  82. E. Bullitt, I. Jung, K. Muller, G. Gerig, S. Aylward, S. Joshi, K. Smith, W. Lin, and M. Ewend, "Lecture notes in computer science," in Medical Image Computing and Computer-Assisted Intervention, MICCAI 2004-7th International Conference, Proceedings, 2004.
  83. Y. Fridman, S. M. Pizer, S. Aylward, and E. Bullitt, "Extracting branching tubular object geometry via cores," Medical image analysis, vol. 8, no. 3, pp. 169--176, 2004.
  84. J. Jomier and S. Aylward, "Rigid and deformable vasculature-to-image registration: a hierarchical approach," Medical Image Computing and Computer-Assisted Intervention--MICCAI 2004, pp. 829--836, 2004.
  85. J. Jomier, E. Rault, and S. R. Aylward, "Automatic quantification of pupil dilation under stress," in Biomedical Imaging: Nano to Macro, 2004. IEEE International Symposium on, 2004, pp. 249--252.
  86. J. Jomier, S. Weeks, and S. R. Aylward, "Vascular image registration for intra-operative 3d ultrasound annotation," in International Congress Series, 2004, p. 1308.
  87. K. C. Kocis, M. Cereda, C. A. Kuroda, H. L. Hurd, S. R. Aylward, E. B. Freid, J. R. Yankaskas, and W. I. Sternberger, "Areadi, a novel ultrasound method for quantifying diaphragm function in adults: 394," Critical Care Medicine, vol. 32, no. 12, p. A109, 2004.
  88. K. A. Tucker, K. R. Robertson, W. Lin, J. K. Smith, H. An, Y. Chen, S. R. Aylward, and C. D. Hall, "Neuroimaging in human immunodeficiency virus infection," Journal of neuroimmunology, vol. 157, no. 1, pp. 153--162, 2004.
  89. S. R. Aylward et al., "Registration and analysis of vascular images," International Journal of Computer Vision, vol. 55, no. 2-3, pp. 123--138, 2003.
  90. S. Aylward and E. Bullitt, "Clinical applications involving vascular image segmentation and registration," in Angiography and Plaque Imaging: Advanced Segmentation Techniques, , Ed., CRC Press, 2003, pp. 451--499.
  91. H. Buchanan, E. Carter, A. W. Conerly, R. Dean, T. Detre, V. Karlis, R. Linsker, M. E. Prime, W. Stead, M. P. Young, and others, "DEPARTMENT OF HEALTH AND HUMAN SERVICES NATIONAL INSTITUTES OF HEALTH NATIONAL LIBRARY OF MEDICINE MINUTES OF THE BOARD OF REGENTS September 9-10, 2003," 2003.
  92. E. Bullitt, G. Gerig, S. Aylward, S. Joshi, K. Smith, M. Ewend, and W. Lin, "Vascular attributes and malignant brain tumors," in International Conference on Medical Image Computing and Computer-Assisted Intervention, 2003, pp. 671--679.
  93. E. Bullitt, G. Gerig, S. M. Pizer, W. Lin, and S. R. Aylward, "Measuring tortuosity of the intracerebral vasculature from mra images," IEEE transactions on medical imaging, vol. 22, no. 9, pp. 1163--1171, 2003.
  94. D. Chillet, J. Jomier, D. Cool, and S. Aylward, "Vascular atlas formation using a vessel-to-image affine registration method," Medical Image Computing and Computer-Assisted Intervention-MICCAI 2003, pp. 335--342, 2003.
  95. D. Cool, D. Chillet, J. Kim, J. Guyon, M. Foskey, and S. Aylward, "Tissue-based affine registration of brain images to form a vascular density atlas," Lecture Notes in Computer Science, vol. 2879, pp. 9--15, 2003.
  96. D. Cool, D. Chillet, J. Kim, J. Guyon, M. Foskey, and S. Aylward, "Tissue-based affine registration of brain images to form a vascular density atlas," in International Conference on Medical Image Computing and Computer-Assisted Intervention, 2003, pp. 9--15.
  97. Y. Fridman, S. Pizer, S. Aylward, and E. Bullitt, "Segmenting 3d branching tubular structures using cores," Medical Image Computing and Computer-Assisted Intervention-MICCAI 2003, pp. 570--577, 2003.
  98. J. Guyon, M. Foskey, J. Kim, Z. Firat, B. Davis, K. Haneke, and S. R. Aylward, "Vetot, volume estimation and tracking over time: framework and validation," in International Conference on Medical Image Computing and Computer-Assisted Intervention, 2003, pp. 142--149.
  99. B. Jolly, H. M. Van, S. Aylward, and E. Bullitt, "Needle tracking and detection in the tips endovascular procedure," in Proc. Medical Image Computing and Computer-Assisted Intervention, 2003, pp. 953--954.
  100. B. Jolly, H. M. Van, S. Aylward, and E. Bullitt, "Needle detection and tracking in the tips endovascular procedure," in International Conference on Medical Image Computing and Computer-Assisted Intervention, 2003, pp. 953--954.
  101. J. Jomier, D. K. Wallace, and S. R. Aylward, "Quantification of retinopathy of prematurity via vessel segmentation," in International Conference on Medical Image Computing and Computer-Assisted Intervention, 2003, pp. 620--626.
  102. S. Laxminarayan and J. S. Suri, "Angiography and plaque imaging: advanced segmentation techniques," 2003.
  103. S. M. Pizer, G. Gerig, S. Joshi, and S. R. Aylward, "Multiscale medial shape-based analysis of image objects," Proceedings of the IEEE, vol. 91, no. 10, pp. 1670--1679, 2003.
  104. D. Wallace, J. A. Capone, J. Jomier, S. Aylward, I. M. Landers, M. Trese, P. S. Group, and others, "Computer automated quantification of plus disease in retcam images of retinopathy of prematurity," Investigative Ophthalmology \& Visual Science, vol. 44, no. 13, pp. 588--588, 2003.
  105. D. K. Wallace, J. Jomier, S. R. Aylward, and M. B. Landers, "Computer-automated quantification of plus disease in retinopathy of prematurity," Journal of American Association for Pediatric Ophthalmology and Strabismus, vol. 7, no. 2, pp. 126--130, 2003.
  106. S. R. Aylward, "Continuous mixture modeling via goodness-of-fit ridges," Pattern recognition, vol. 35, no. 9, pp. 1821--1833, 2002.
  107. S. R. Aylward and E. Bullitt, "Initialization, noise, singularities, and scale in height ridge traversal for tubular object centerline extraction," IEEE transactions on medical imaging, vol. 21, no. 2, pp. 61--75, 2002.
  108. S. R. Aylward et al., "Intra-operative 3d ultrasound augmentation," in Biomedical Imaging, 2002. Proceedings. 2002 IEEE International Symposium on, 2002, pp. 421--424.
  109. E. Bullitt and S. Aylward, "Patient-specific vascular models for endovascular and open operative procedures," in International Congress Series, 2002, pp. 129--138.
  110. E. Bullitt and S. R. Aylward, "Volume rendering of segmented image objects," IEEE Transactions on Medical Imaging, vol. 21, no. 8, pp. 998--1002, 2002.
  111. L. Ibanez, L. Ng, J. Gee, and S. Aylward, "Registration patterns: the generic framework for image registration of the insight toolkit," in Biomedical Imaging, 2002. Proceedings. 2002 IEEE International Symposium on, 2002, pp. 345--348.
  112. T. S. Yoo, M. J. Ackerman, W. E. Lorensen, W. Schroeder, V. Chalana, S. Aylward, D. Metaxas, and R. Whitaker, "Engineering and algorithm design for an image processing api: a technical report on itk-the insight toolkit," Studies in health technology and informatics, pp. 586--592, 2002.
  113. S. Aylward et al., "Analysis of the parameter space of a metric for registering 3d vascular images," in Medical Image Computing and Computer-Assisted Intervention--MICCAI 2001, 2001, pp. 932--939.
  114. E. Bullitt and S. Aylward, "Volume rendering of segmented tubular objects," in International Conference on Medical Image Computing and Computer-Assisted Intervention, 2001, pp. 161--168.
  115. E. Bullitt and S. R. Aylward, "Analysis of time-varying images using 3d vascular models," in Applied Imagery Pattern Recognition Workshop, AIPR 2001 30th, 2001, pp. 9--14.
  116. E. Bullitt, S. Aylward, J. E. J. Bernard, and G. Gerig, "Computer-assisted visualization of arteriovenous malformations on the home personal computer," Neurosurgery, vol. 48, no. 3, pp. 576--583, 2001.
  117. E. Bullitt, S. Aylward, K. Smith, S. Mukherji, M. Jiroutek, and K. Muller, "Symbolic description of intracerebral vessels segmented from magnetic resonance angiograms and evaluation by comparison with x-ray angiograms," Medical Image Analysis, vol. 5, no. 2, pp. 157--169, 2001.
  118. M. Rosenthal, S. Weeks, S. Aylward, E. Bullitt, and H. Fuchs, "Intraoperative tracking of anatomical structures using fluoroscopy and a vascular balloon catheter," in Proceedings of the 4th International Conference on Medical Image Computing and Computer-Assisted Intervention, 2001, pp. 1253--1254.
  119. S. Weeks, K. Wilber, and S. Aylward, "Volume estimations using conventional hand tracing techniques vs automatic thresholding techniques: can we be more accurate and save time?," in RADIOLOGY, 2001, pp. 119--119.
  120. R. J. Gerstle, S. R. Aylward, S. Kromhout-Schiro, and S. K. Mukherji, "The role of neural networks in improving the accuracy of mr spectroscopy for the diagnosis of head and neck squamous cell carcinoma," American journal of neuroradiology, vol. 21, no. 6, pp. 1133--1138, 2000.
  121. E. D. Pisano, E. B. Cole, B. M. Hemminger, M. J. Yaffe, S. R. Aylward, A. D. Maidment, R. E. Johnston, M. B. Williams, L. T. Niklason, E. F. Conant, and others, "Image processing algorithms for digital mammography: a pictorial essay 1," Radiographics, vol. 20, no. 5, pp. 1479--1491, 2000.
  122. E. D. Pisano, E. B. Cole, S. Major, S. Zong, B. M. Hemminger, K. E. Muller, R. E. Johnston, R. Walsh, E. Conant, L. L. Fajardo, and others, "Radiologists preferences for digital mammographic display 1," Radiology, vol. 216, no. 3, pp. 820--830, 2000.
  123. E. Bullitt, S. Aylward, A. Liu, J. Stone, S. K. Mukherji, C. Coffey, G. Gerig, and S. M. Pizer, "3d graph description of the intracerebral vasculature from segmented mra and tests of accuracy by comparison with x-ray angiograms," in Biennial International Conference on Information Processing in Medical Imaging, 1999, pp. 308--321.
  124. E. Bullitt, A. Liu, S. R. Aylward, C. Coffey, J. Stone, S. K. Mukherji, K. E. Muller, and S. M. Pizer, "Registration of 3d cerebral vessels with 2d digital angiograms: clinical evaluation," Academic Radiology, vol. 6, no. 9, pp. 539--546, 1999.
  125. B. Hemminger, E. Cole, S. Zong, M. Yaffe, S. Aylward, A. Maidment, M. Williams, L. Niklason, R. Johnston, and E. Pisano, "Evaluation of digital processing methods for the display of digital mammography [3658-44]," in PROCEEDINGS-SPIE THE INTERNATIONAL SOCIETY FOR OPTICAL ENGINEERING, 1999, pp. 382--395.
  126. B. M. Hemminger, E. Cole, S. Zong, M. J. Yaffe, S. Aylward, A. D. Maidment, M. B. Williams, L. T. Niklason, R. E. Johnston, and E. D. Pisano, "Evaluation of digital processing methods for the display of digital mammography," in Medical Imaging'99, 1999, pp. 382--393.
  127. E. Pisano, B. Hemminger, S. Sthapit, S. Aylward, E. Cole, and R. Johnston, "Comparison of speed and accuracy of a digital mammography softcopy display system vs. printed film display," in RADIOLOGY, 1999, pp. 322--322.
  128. S. Aylward et al., "Vtree3d: fast and effective vessel, bronchial tube, duct, and bone display," in RADIOLOGY, 1998, pp. 394--394.
  129. S. R. Aylward et al., "Mixture modeling for digital mammogram display and analysis," in Digital Mammography, , Ed., Springer Netherlands, 1998, pp. 305--312.
  130. R. Gerstle, S. Aylward, S. Mukherji, S. Schiro, and K. Muller, "Neural network and statistical analysis of proton mr spectroscopy in the diagnosis of laryngeal carcinoma," in RADIOLOGY, 1998, pp. 151--151.
  131. S. R. Aylward, "Continuous mixture modeling via goodness-of-fit cores," Medical Physics, vol. 24, no. 7, pp. 1182--1182, 1997.
  132. S. Aylward and S. Pizer, "Continuous gaussian mixture modeling," in Information Processing in Medical Imaging, 1997, pp. 176--189.
  133. E. Bullitt, A. Liu, S. Aylward, and S. M. Pizer, "3d reconstruction of aneurysms from projection angiograms," British Journal of Neurosurgery, vol. 11, no. 5, pp. 458--459, 1997.
  134. E. Bullitt, A. Liu, S. Aylward, and S. Pizer, "Reconstruction of the intracerebral vasculature from mra and a pair of projection views," in Information Processing in Medical Imaging, 1997, pp. 537--542.
  135. E. Bullitt, A. Liu, S. Aylward, M. Soltys, J. Rosenman, and S. M. Pizer, "Methods for displaying intracerebral vascular anatomy.," American journal of neuroradiology, vol. 18, no. 3, pp. 417--420, 1997.
  136. S. Aylward et al., "Intensity ridge and widths for tubular object segmentation and description," in Mathematical Methods in Biomedical Image Analysis, 1996., Proceedings of the Workshop on, 1996, pp. 131--138.
  137. G. E. Peterson, D. S. Clair, S. R. Aylward, and W. E. Bond, "Using taguchi's method of experimental design to control errors in layered perceptrons," IEEE transactions on neural networks, vol. 6, no. 4, pp. 949--961, 1995.
  138. S. Aylward et al., "Spatially invariant classification of tissues in mr images [2359-31]," in PROCEEDINGS-SPIE THE INTERNATIONAL SOCIETY FOR OPTICAL ENGINEERING, 1994, pp. 352--352.
  139. S. Aylward et al., "The effects of magnetic resonance image inhomogeneities on automated tissue classification," TR94-021, University of North Carolina, Chapel Hill, 1994.
  140. S. Aylward et al., "Spatially invariant classification of tissues in mr images," in Proceedings of the Third Conference on Visualization in Biomedical Computing. SPIE, 1994.
  141. R. J. Anderson and S. R. Aylward, "Lab testing of neural networks for improved aircraft onboard-diagnostics on flight-ready hardware," in Reliability and Maintainability Symposium, 1993. Proceedings., Annual, 1993, pp. 404--410.
  142. D. C. S. Clair, G. E. Peterson, S. Aylward, and W. E. Bond, "Design techniques for the control of errors in backpropagation neural networks," in Optical Engineering and Photonics in Aerospace Sensing, 1993, pp. 372--383.
  143. C. D. St., G. Peterson, S. Aylward, and W. Bond, "Design techniques for the control of errors in backpropagation neural networks [1966-26]," in PROCEEDINGS-SPIE THE INTERNATIONAL SOCIETY FOR OPTICAL ENGINEERING, 1993, pp. 372--372.
  144. W. E. Bond, C. D. St, M. Amirfathi, C. J. Merz, and S. Aylward, "Neural network analysis of nondestructive evaluation patterns," in Proceedings of the 1992 ACM/SIGAPP symposium on Applied computing: technological challenges of the 1990's, 1992, pp. 643--650.
  145. C. D. C. St, W. E. Bond, A. Rigler, and S. Aylward, "An evaluation of learning performance in backpropagation neural networks and decision-tree classifier systems," in Proceedings of the 1992 ACM/SIGAPP symposium on Applied computing: technological challenges of the 1990's, 1992, pp. 636--642.
  146. S. AYLWARD and R. ANDERSON, "An algorithm for neural network architecture generation," in 8th Computing in Aerospace Conference, 1991, p. 3756.
  147. D. C. S. Clair, W. Bond, A. Rigler, and S. Aylward, "Evaluation of neural network and decision-tree classifier system performance using learning accuracy techniques," in Intelligent engineering systems through artificial neural networks: proceedings of the Artificial Neural Networks in Engineering (ANNIE'91) Conference, held November 10-13, 1991, in St. Louis, Missouri, USA, 1991, p. 161.
  148. A. Rigler and S. Aylward, "Evaluation of neural network and decision-tree classifier system performance using learning accuracy techniques daniel c. st. clair* university of missouri-rolla," in Intelligent Engineering Systems Through Artificial Neural Networks: Proceedings of the Artificial Neural Networks in Engineering (ANNIE...) Conference, 1991, p. 161.
  149. D. Cool, J. Jomier, M. Foskey, and S. Aylward, "Improved Inter-Subject Spatial Localization of Neuro-Functional Activation through Cerebrovascular Alignment,".
  150. J. Jomier and S. R. Aylward, "Vessel to image registration using rigid and elastic transformations," Procs MICCAI, vol. 3.
  151. M. Jomier, J. Jomier, G. Gerig, and S. R. Aylward, "Registering Fiber Tracts with Fractional Anisotropy for Functional Sites Localization,".