Puppies cry when researchers disappoint the public
by circumventing data-sharing guidelines
“Data Submission and Quality in Microarray-Based MicroRNA Profiling”
“Overall, data submission was reported at publication for <40%
of all articles, and almost 75% of articles were MIAME noncompliant.”
In the micro-RNA field:
Minimum Information About a Microarray Experiment
(MIAME) standards are supposedly required by journals.
Not surprisingly, the articles that did not share data also had lower scores.
One of those articles had to be retracted:
“Upon re-evaluation of the analyses performed, we discovered an error in the data fed into the software, which resulted in incorrect results in Table 2 and Figure 2. During the initial analysis, we eliminated miRNAs if they showed an expression CT of value 35 in over 75% of the samples. This decision was based on the instructions from the software during the initial data feed process for the selection of particular miRNAs (row) for exclusion. Unfortunately, the software included the excluded miRNAs as controls along with the endogenous controls and analyzed the data. As a result, the analyses identified miRNAs that are not statistically significant.”
This reinforces the principle that only Open Science can be Real Science,
because only with Open Data can independent parties replicate the results reported by authors.
Real Scientific Papers publish with Open Data.
Saturday February 23th,
Join us to celebrate